Research in our lab spans from basic biology to translational medicine in the areas of cellular reprogramming, immunoengineering and nanomedicine.
In situ cell reprogramming
Transcription factors can induce changes in cell fate and identity, and in biological age, throughout an organism's lifespan. We take advantage of this to develop approaches that reprogram cells in vivo and ultimately enhance the regeneration of injured or aged tissues.
Immune cells discern between foreign and self and are able to fight infection or disease (e.g., cancer) while preserving healthy tissues intact, but under certain circumstances this ability can be lost leading to autoimmunity, infection or neoplastic disease. We explore immunoengineering approaches to restore or augment immune function in the context of autoimmunity and cancer, respectively.
Nanoscale carriers can improve the delivery of small molecule drugs and biologicals (e.g. nucleic acids, proteins, peptides...) by helping them localizing where they are needed or by protecting them from degradation. Our lab engineers nanomedicines for diverse applications, including cell reprogramming and immuno-engineering.